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Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations
Pb is a potential risk factor for cognition, mainly mediated by enhanced oxidative stress. Resveratrol, a natural polyphenol with crucial anti-oxidative property, is recently implicated in preventing cognitive deficits in normal aging and neurodegenerative disorders. Its beneficial effects have been...
Autores principales: | Zhang, Lijie, Tu, Runqi, Wang, Yawei, Hu, Yazhen, Li, Xing, Cheng, Xuemin, Yin, Yanyan, Li, Wenjie, Huang, Hui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489681/ https://www.ncbi.nlm.nih.gov/pubmed/28706491 http://dx.doi.org/10.3389/fphys.2017.00446 |
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