HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients

Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases. This provides the rationale for HSP90 inhibitors as cancer therapeutics. However, the mechanism by which HSP90 ATPase inhibi...

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Detalles Bibliográficos
Autores principales: Li, Zhaobo, Zhou, Lihong, Prodromou, Chrisostomos, Savic, Velibor, Pearl, Laurence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489699/
https://www.ncbi.nlm.nih.gov/pubmed/28636940
http://dx.doi.org/10.1016/j.celrep.2017.05.078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489699/
https://www.ncbi.nlm.nih.gov/pubmed/28636940
http://dx.doi.org/10.1016/j.celrep.2017.05.078

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