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Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms
Computational modelling of metabolic networks has become an established procedure in the metabolic engineering of production strains. One key principle that is frequently used to guide the rational design of microbial cell factories is the stoichiometric coupling of growth and product synthesis, whi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489714/ https://www.ncbi.nlm.nih.gov/pubmed/28639622 http://dx.doi.org/10.1038/ncomms15956 |