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Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to promote blood flow, to treat anemia, and is used as sedative or tonic agent. The root contains various bioacti...

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Autores principales: Sowndhararajan, Kandhasamy, Kim, Songmun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489925/
https://www.ncbi.nlm.nih.gov/pubmed/28452965
http://dx.doi.org/10.3390/scipharm85020021
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author Sowndhararajan, Kandhasamy
Kim, Songmun
author_facet Sowndhararajan, Kandhasamy
Kim, Songmun
author_sort Sowndhararajan, Kandhasamy
collection PubMed
description Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to promote blood flow, to treat anemia, and is used as sedative or tonic agent. The root contains various bioactive metabolites; in particular, decursin and decursinol (pyranocoumarin type components) have been reported to possess various pharmacological properties. Recently, several in vitro and in vivo studies have reported that the crude extracts and isolated components from the root of A. gigas exhibited neuroprotective and cognitive enhancement effects. Neuronal damage or death is the most important factor for many neurodegenerative diseases. In addition, recent studies have clearly demonstrated the possible mechanisms behind the neuroprotective action of extracts/compounds from the root of A. gigas. In the present review, we summarized the neuroprotective and cognitive enhancement effects of extracts and individual compounds from A. gigas root.
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spelling pubmed-54899252017-07-05 Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review Sowndhararajan, Kandhasamy Kim, Songmun Sci Pharm Review Angelica gigas Nakai is an important medicinal plant with health promoting properties that is used to treat many disorders. In traditional herbal medicine, the root of this plant is used to promote blood flow, to treat anemia, and is used as sedative or tonic agent. The root contains various bioactive metabolites; in particular, decursin and decursinol (pyranocoumarin type components) have been reported to possess various pharmacological properties. Recently, several in vitro and in vivo studies have reported that the crude extracts and isolated components from the root of A. gigas exhibited neuroprotective and cognitive enhancement effects. Neuronal damage or death is the most important factor for many neurodegenerative diseases. In addition, recent studies have clearly demonstrated the possible mechanisms behind the neuroprotective action of extracts/compounds from the root of A. gigas. In the present review, we summarized the neuroprotective and cognitive enhancement effects of extracts and individual compounds from A. gigas root. MDPI 2017-04-28 2017 /pmc/articles/PMC5489925/ /pubmed/28452965 http://dx.doi.org/10.3390/scipharm85020021 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sowndhararajan, Kandhasamy
Kim, Songmun
Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review
title Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review
title_full Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review
title_fullStr Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review
title_full_unstemmed Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review
title_short Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review
title_sort neuroprotective and cognitive enhancement potentials of angelica gigas nakai root: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489925/
https://www.ncbi.nlm.nih.gov/pubmed/28452965
http://dx.doi.org/10.3390/scipharm85020021
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