Comparison of Direct Sequencing, Real-Time PCR-High Resolution Melt (PCR-HRM) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) Analysis for Genotyping of Common Thiopurine Intolerant Variant Alleles NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C)

Thiopurine intolerance and treatment-related toxicity, such as fatal myelosuppression, is related to non-function genetic variants encoding thiopurine S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15). Genetic testing of the common variants NUDT15:NM_018283.2:c.415C>T (Arg139Cys, dbSNP r...

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Detalles Bibliográficos
Autores principales: Fong, Wai-Ying, Ho, Chi-Chun, Poon, Wing-Tat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489947/
https://www.ncbi.nlm.nih.gov/pubmed/28498350
http://dx.doi.org/10.3390/diagnostics7020027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489947/
https://www.ncbi.nlm.nih.gov/pubmed/28498350
http://dx.doi.org/10.3390/diagnostics7020027

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