Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential

Two transient receptor potential (TRP) channels—TRPA1 and TRPV3—are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity. The enzymes responsible are the HIF prolyl hydroxylases (PHDs) and the asparaginyl hydroxylase factor inhibiting HIF (FIH). The PHDs an...

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Detalles Bibliográficos
Autores principales: Nagarajan, Yagnesh, Rychkov, Grigori Y., Peet, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490392/
https://www.ncbi.nlm.nih.gov/pubmed/28346371
http://dx.doi.org/10.3390/ph10020035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490392/
https://www.ncbi.nlm.nih.gov/pubmed/28346371
http://dx.doi.org/10.3390/ph10020035

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