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Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential

Two transient receptor potential (TRP) channels—TRPA1 and TRPV3—are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity. The enzymes responsible are the HIF prolyl hydroxylases (PHDs) and the asparaginyl hydroxylase factor inhibiting HIF (FIH). The PHDs an...

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Detalles Bibliográficos
Autores principales:	Nagarajan, Yagnesh, Rychkov, Grigori Y., Peet, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490392/ https://www.ncbi.nlm.nih.gov/pubmed/28346371 http://dx.doi.org/10.3390/ph10020035

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