Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

A novel plant sesquiterpene lactone derivative, DET derivative (DETD)-35, originating from parental deoxyelephantopin (DET) was previously observed to effectively suppress human triple negative breast cancer (TNBC) MDA-MB-231 cell activity and tumor growth in mice. In this study, the mechanisms unde...

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Detalles Bibliográficos
Autores principales: Shiau, Jeng-Yuan, Chang, Yong-Qun, Nakagawa-Goto, Kyoko, Lee, Kuo-Hsiung, Shyur, Lie-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490438/
https://www.ncbi.nlm.nih.gov/pubmed/28706483
http://dx.doi.org/10.3389/fphar.2017.00398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490438/
https://www.ncbi.nlm.nih.gov/pubmed/28706483
http://dx.doi.org/10.3389/fphar.2017.00398

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