Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increased Ca(2+) release. Mice underwent continuous isopr...

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Detalles Bibliográficos
Autores principales: Gao, Mei Hua, Lai, N. Chin, Giamouridis, Dimosthenis, Kim, Young Chul, Tan, Zhen, Guo, Tracy, Dillmann, Wolfgang H., Suarez, Jorge, Hammond, H. Kirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490496/
https://www.ncbi.nlm.nih.gov/pubmed/28670631
http://dx.doi.org/10.1016/j.jacbts.2016.08.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490496/
https://www.ncbi.nlm.nih.gov/pubmed/28670631
http://dx.doi.org/10.1016/j.jacbts.2016.08.004

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