Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer

Hyperactivation of the phosphatydil-inositol-3' phosphate kinase (PI3K)/AKT pathway is observed in most NSCLCs, promoting proliferation, migration, invasion and resistance to therapy. AKT can be activated through several mechanisms that include loss of the negative regulator PTEN, activating mu...

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Detalles Bibliográficos
Autores principales: De Marco, Carmela, Laudanna, Carmelo, Rinaldo, Nicola, Oliveira, Duarte Mendes, Ravo, Maria, Weisz, Alessandro, Ceccarelli, Michele, Caira, Elvira, Rizzuto, Antonia, Zoppoli, Pietro, Malanga, Donatella, Viglietto, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491004/
https://www.ncbi.nlm.nih.gov/pubmed/28662101
http://dx.doi.org/10.1371/journal.pone.0178865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491004/
https://www.ncbi.nlm.nih.gov/pubmed/28662101
http://dx.doi.org/10.1371/journal.pone.0178865

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