Extreme low dose of 5-fluorouracil reverses MDR in cancer by sensitizing cancer associated fibroblasts and down-regulating P-gp

We conducted a prospective, meaningful study of extreme low dose of 5-fluorouracil (5FU) as a metronomic agent targeting cancer associated fibroblasts (CAFs) to reverse Multidrug resistance (MDR) by sensitizing cancer associated fibroblasts and down-regulating P-glycoprotein (P-gp). The combination...

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Detalles Bibliográficos
Autores principales: Ma, Yan, Wang, Yuhua, Xu, Zhenghong, Wang, Yongjun, Fallon, John K., Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491115/
https://www.ncbi.nlm.nih.gov/pubmed/28662182
http://dx.doi.org/10.1371/journal.pone.0180023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491115/
https://www.ncbi.nlm.nih.gov/pubmed/28662182
http://dx.doi.org/10.1371/journal.pone.0180023

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