Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution

Endothelial cells line the lumen of the vessel wall and are exposed to flow. In linear parts of the vessel, the endothelial cells experience laminar flow, resulting in endothelial cell alignment in the direction of flow, thereby protecting the vessel wall from inflammation and permeability. In order...

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Detalles Bibliográficos
Autores principales: Kroon, Jeffrey, Heemskerk, Niels, Kalsbeek, Martin J. T., de Waard, Vivian, van Rijssel, Jos, van Buul, Jaap D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491183/
https://www.ncbi.nlm.nih.gov/pubmed/28515142
http://dx.doi.org/10.1091/mbc.E16-06-0389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491183/
https://www.ncbi.nlm.nih.gov/pubmed/28515142
http://dx.doi.org/10.1091/mbc.E16-06-0389

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