Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs

Systemic sclerosis (SSc) is a devastating disease affecting the skin and internal organs. Dermal fibrosis manifests early and Modified Rodnan Skin Scores (MRSS) correlate with disease progression. Transcriptomics of SSc skin biopsies suggest the role of the in vivo microenvironment in maintaining th...

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Detalles Bibliográficos
Autores principales: Cao, Lizhi, Lafyatis, Robert, Burkly, Linda C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491269/
https://www.ncbi.nlm.nih.gov/pubmed/28662216
http://dx.doi.org/10.1371/journal.pone.0180751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491269/
https://www.ncbi.nlm.nih.gov/pubmed/28662216
http://dx.doi.org/10.1371/journal.pone.0180751

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