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Inferring repeat-protein energetics from evolutionary information

Natural protein sequences contain a record of their history. A common constraint in a given protein family is the ability to fold to specific structures, and it has been shown possible to infer the main native ensemble by analyzing covariations in extant sequences. Still, many natural proteins that...

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Detalles Bibliográficos
Autores principales: Espada, Rocío, Parra, R. Gonzalo, Mora, Thierry, Walczak, Aleksandra M., Ferreiro, Diego U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491312/
https://www.ncbi.nlm.nih.gov/pubmed/28617812
http://dx.doi.org/10.1371/journal.pcbi.1005584