Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization

PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signalling. Due to its critical role in suppressing the potent signalling pathway, it is one of the most mutated tumour suppressors, especially in brain tumours. It is generally thought that PTEN deficiencies predominantly result from...

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Detalles Bibliográficos
Autores principales: Yang, Jr-M, Schiapparelli, P, Nguyen, H-N, Igarashi, A, Zhang, Q, Abbadi, S, Amzel, L M, Sesaki, H, Quiñones-Hinojosa, A, Iijima, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491373/
https://www.ncbi.nlm.nih.gov/pubmed/28263967
http://dx.doi.org/10.1038/onc.2016.493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491373/
https://www.ncbi.nlm.nih.gov/pubmed/28263967
http://dx.doi.org/10.1038/onc.2016.493

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