Targeting Visceral Fat by Intraperitoneal Delivery of Novel AAV Serotype Vector Restricting Off-Target Transduction in Liver

It is challenging to genetically manipulate fat in adults. We demonstrate that intraperitoneal (i.p.) injection of an engineered adeno-associated virus (AAV) serotype Rec2 leads to high transduction of multiple visceral fat depots at a dose of 1 to 2 orders lower than commonly used doses for systemi...

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Detalles Bibliográficos
Autores principales: Huang, Wei, Liu, Xianglan, Queen, Nicholas J., Cao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491462/
https://www.ncbi.nlm.nih.gov/pubmed/28702474
http://dx.doi.org/10.1016/j.omtm.2017.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491462/
https://www.ncbi.nlm.nih.gov/pubmed/28702474
http://dx.doi.org/10.1016/j.omtm.2017.06.002

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