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Targeting Visceral Fat by Intraperitoneal Delivery of Novel AAV Serotype Vector Restricting Off-Target Transduction in Liver

It is challenging to genetically manipulate fat in adults. We demonstrate that intraperitoneal (i.p.) injection of an engineered adeno-associated virus (AAV) serotype Rec2 leads to high transduction of multiple visceral fat depots at a dose of 1 to 2 orders lower than commonly used doses for systemi...

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Detalles Bibliográficos
Autores principales:	Huang, Wei, Liu, Xianglan, Queen, Nicholas J., Cao, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491462/ https://www.ncbi.nlm.nih.gov/pubmed/28702474 http://dx.doi.org/10.1016/j.omtm.2017.06.002

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