Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Here, we report that physiological nuclear TDP-43 in mouse and human brain forms ho...

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Detalles Bibliográficos
Autores principales: Afroz, Tariq, Hock, Eva-Maria, Ernst, Patrick, Foglieni, Chiara, Jambeau, Melanie, Gilhespy, Larissa A. B., Laferriere, Florent, Maniecka, Zuzanna, Plückthun, Andreas, Mittl, Peer, Paganetti, Paolo, Allain, Frédéric H. T., Polymenidou, Magdalini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491494/
https://www.ncbi.nlm.nih.gov/pubmed/28663553
http://dx.doi.org/10.1038/s41467-017-00062-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491494/
https://www.ncbi.nlm.nih.gov/pubmed/28663553
http://dx.doi.org/10.1038/s41467-017-00062-0

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