Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation

Transcription factor C/EBPα is a master regulator of myelopoiesis and its inactivation is associated with acute myeloid leukemia. Deregulation of C/EBPα by microRNAs during granulopoiesis or acute myeloid leukemia development has not been studied. Here we show that oncogenic miR-182 is a strong regu...

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Detalles Bibliográficos
Autores principales: Wurm, Alexander Arthur, Zjablovskaja, Polina, Kardosova, Miroslava, Gerloff, Dennis, Bräuer-Hartmann, Daniela, Katzerke, Christiane, Hartmann, Jens-Uwe, Benoukraf, Touati, Fricke, Stephan, Hilger, Nadja, Müller, Anne-Marie, Bill, Marius, Schwind, Sebastian, Tenen, Daniel G., Niederwieser, Dietger, Alberich-Jorda, Meritxell, Behre, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491528/
https://www.ncbi.nlm.nih.gov/pubmed/28663557
http://dx.doi.org/10.1038/s41467-017-00032-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491528/
https://www.ncbi.nlm.nih.gov/pubmed/28663557
http://dx.doi.org/10.1038/s41467-017-00032-6

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