Cargando…

Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation

Transcription factor C/EBPα is a master regulator of myelopoiesis and its inactivation is associated with acute myeloid leukemia. Deregulation of C/EBPα by microRNAs during granulopoiesis or acute myeloid leukemia development has not been studied. Here we show that oncogenic miR-182 is a strong regu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wurm, Alexander Arthur, Zjablovskaja, Polina, Kardosova, Miroslava, Gerloff, Dennis, Bräuer-Hartmann, Daniela, Katzerke, Christiane, Hartmann, Jens-Uwe, Benoukraf, Touati, Fricke, Stephan, Hilger, Nadja, Müller, Anne-Marie, Bill, Marius, Schwind, Sebastian, Tenen, Daniel G., Niederwieser, Dietger, Alberich-Jorda, Meritxell, Behre, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491528/ https://www.ncbi.nlm.nih.gov/pubmed/28663557 http://dx.doi.org/10.1038/s41467-017-00032-6

Ejemplares similares

ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia
por: Namasu, Carolina Yaeko, et al.
Publicado: (2017)

MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia
por: Hartmann, Jens-Uwe, et al.
Publicado: (2018)

miR-451a abrogates treatment resistance in FLT3-ITD-positive acute myeloid leukemia
por: Krakowsky, Rosanna H. E., et al.
Publicado: (2018)

Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation
por: Lobo de Figueiredo-Pontes, Lorena, et al.
Publicado: (2022)

Nutritional Status at Diagnosis and Pre-transplant Weight Loss Impact Outcomes of Acute Myeloid Leukemia Patients Following Allogeneic Stem Cell Transplantation
por: Brauer, Dominic, et al.
Publicado: (2021)

LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes
por: Suh, Hyung C., et al.
Publicado: (2017)

The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?
por: Wurm, Alexander Arthur, et al.
Publicado: (2017)

PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development
por: Zhao, Xinhui, et al.
Publicado: (2022)

High expression of the stem cell marker GPR56 at diagnosis identifies acute myeloid leukemia patients at higher relapse risk after allogeneic stem cell transplantation with the CD34(+)/CD38(-) population
por: Jentzsch, Madlen, et al.
Publicado: (2020)

Allogeneic stem cell transplantation mitigates the adverse prognostic impact of high diagnostic BAALC and MN1 expression in AML
por: Jentzsch, Madlen, et al.
Publicado: (2020)

ELN risk stratification and outcomes in secondary and therapy-related AML patients consolidated with allogeneic stem cell transplantation
por: Jentzsch, Madlen, et al.
Publicado: (2020)

Prognostic relevance of remission and measurable residual disease status in AML patients prior to reduced intensity or non-myeloablative allogeneic stem cell transplantation
por: Jentzsch, Madlen, et al.
Publicado: (2021)

A high hematopoietic cell transplantation comorbidity Index (HCT-CI) does not impair outcomes after non-myeloablative allogeneic stem cell transplantation in acute myeloid leukemia patients 60 years or older
por: Backhaus, Donata, et al.
Publicado: (2022)

Impact of MRD status in patients with AML undergoing allogeneic stem cell transplantation in the first vs the second remission
por: Jentzsch, Madlen, et al.
Publicado: (2022)

Incubation of Immune Cell Grafts With MAX.16H5 IgG1 Anti-Human CD4 Antibody Prolonged Survival After Hematopoietic Stem Cell Transplantation in a Mouse Model for Fms Like Tyrosine Kinase 3 Positive Acute Myeloid Leukemia
por: Hilger, Nadja, et al.
Publicado: (2018)

Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism
por: Rychtarcikova, Zuzana, et al.
Publicado: (2016)

High BAALC copy numbers in peripheral blood prior to allogeneic transplantation predict early relapse in acute myeloid leukemia patients
por: Jentzsch, Madlen, et al.
Publicado: (2017)

The Chinese HCT survey: a non-manipulated haploidentical transplantation procedure makes a novel contribution to data sharing within the regional and global transplant registries and to worldwide knowledge
por: Niederwieser, Dietger
Publicado: (2021)

Measurable residual disease of canonical versus non-canonical DNMT3A, TET2, or ASXL1 mutations in AML at stem cell transplantation
por: Jentzsch, Madlen, et al.
Publicado: (2021)

Outcomes of Older Patients with NPM1 Mutated and FLT3-ITD Negative Acute Myeloid Leukemia Receiving Allogeneic Transplantation
por: Jentzsch, Madlen, et al.
Publicado: (2020)

Prognostic Impact of Blood MN1 Copy Numbers Before Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia
por: Jentzsch, Madlen, et al.
Publicado: (2019)

Biosimilar agents in oncology/haematology: from approval to practice
por: Niederwieser, Dietger, et al.
Publicado: (2011)

DNMT1-interacting RNAs block gene specific DNA methylation
por: Di Ruscio, Annalisa, et al.
Publicado: (2013)

The diagnostic red blood cell distribution width as a prognostic factor in acute myeloid leukemia
por: Vucinic, Vladan, et al.
Publicado: (2021)

Correspondence on NanoVar’s performance outlined by Jiang T. et al. in “Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation”
por: Tham, Cheng Yong, et al.
Publicado: (2023)

High-speed automatic characterization of rare events in flow cytometric data
por: Qi, Yuan, et al.
Publicado: (2020)

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein α (C/EBPα) Is Critical for Granulopoiesis
por: Zhang, Pu, et al.
Publicado: (1998)

Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα
por: Sridhar, Radhakrishnan, et al.
Publicado: (2018)

Case Report: Graft Versus Tumor Effect After Non-Myeloablative Allogeneic Stem-Cell Transplantation in a Patient With Brentuximab-Vedotin Refractory Sezary Syndrome
por: Franke, Georg-Nikolaus, et al.
Publicado: (2021)

Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation
por: Bill, Marius, et al.
Publicado: (2022)

Acetylation of C/EBPα inhibits its granulopoietic function
por: Bararia, Deepak, et al.
Publicado: (2016)

P450: ALDH1A AS A THERAPEUTIC TARGET IN ACUTE MYELOID LEUKEMIA
por: Shaikh, Mehak, et al.
Publicado: (2023)

C/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence
por: Ye, Min, et al.
Publicado: (2013)

Down regulation of PSA by C/EBPα is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell Line
por: Yin, Hong, et al.
Publicado: (2006)

The activities and regulatory landscape of cellular therapies including hematopoietic cell transplantation in the world
por: Okamoto, Shinichiro, et al.
Publicado: (2022)

TFregulomeR reveals transcription factors’ context-specific features and functions
por: Lin, Quy Xiao Xuan, et al.
Publicado: (2020)

Allogeneic stem cell transplantation for mantle cell lymphoma—update of the prospective trials of the East German Study Group Hematology/Oncology (OSHO#60 and #74)
por: Krüger, William H., et al.
Publicado: (2021)

Whole genome DNA methylation: beyond genes silencing
por: Tirado-Magallanes, Roberto, et al.
Publicado: (2016)

Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma
por: Lobo de Figueiredo-Pontes, Lorena, et al.
Publicado: (2021)

E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation
por: Pal, P, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_q08tc7pt60eqokkpm6crl87mhs