The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation

AIMS/HYPOTHESIS: Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger NOD-like receptor pyrin domain containing-3 (NL...

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Detalles Bibliográficos
Autores principales: Kulak, Klaudia, Westermark, Gunilla T., Papac-Milicevic, Nikolina, Renström, Erik, Blom, Anna M., King, Ben C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491568/
https://www.ncbi.nlm.nih.gov/pubmed/28500395
http://dx.doi.org/10.1007/s00125-017-4286-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491568/
https://www.ncbi.nlm.nih.gov/pubmed/28500395
http://dx.doi.org/10.1007/s00125-017-4286-3

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