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The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation

AIMS/HYPOTHESIS: Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger NOD-like receptor pyrin domain containing-3 (NL...

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Detalles Bibliográficos
Autores principales:	Kulak, Klaudia, Westermark, Gunilla T., Papac-Milicevic, Nikolina, Renström, Erik, Blom, Anna M., King, Ben C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491568/ https://www.ncbi.nlm.nih.gov/pubmed/28500395 http://dx.doi.org/10.1007/s00125-017-4286-3

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