Cargando…

Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation

We recently proved that exosomes engineered in vitro to deliver high amounts of HPV E7 upon fusion with the Nef(mut) exosome-anchoring protein elicit an efficient anti-E7 cytotoxic T lymphocyte immune response. However, in view of a potential clinic application of this finding, our exosome-based imm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Bonito, Paola, Chiozzini, Chiara, Arenaccio, Claudia, Anticoli, Simona, Manfredi, Francesco, Olivetta, Eleonora, Ferrantelli, Flavia, Falcone, Emiliana, Ruggieri, Anna, Federico, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491702/ https://www.ncbi.nlm.nih.gov/pubmed/28694699 http://dx.doi.org/10.2147/IJN.S131309

Ejemplares similares

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1
por: Arenaccio, Claudia, et al.
Publicado: (2015)

HPV-E7 Delivered by Engineered Exosomes Elicits a Protective CD8(+) T Cell-Mediated Immune Response
por: Di Bonito, Paola, et al.
Publicado: (2015)

The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells
por: Ferrantelli, Flavia, et al.
Publicado: (2019)

The CD8(+) T Cell-Mediated Immunity Induced by HPV-E6 Uploaded in Engineered Exosomes Is Improved by ISCOMATRIX(TM) Adjuvant
por: Manfredi, Francesco, et al.
Publicado: (2016)

Long-Term Antitumor CD8(+) T Cell Immunity Induced by Endogenously Engineered Extracellular Vesicles
por: Ferrantelli, Flavia, et al.
Publicado: (2021)

The C-Terminal Domain of Nef(mut) Is Dispensable for the CD8(+) T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2021)

N-Terminal Fatty Acids of NEF(MUT) Are Required for the CD8(+) T-Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2020)

Engineered Extracellular Vesicles/Exosomes as a New Tool against Neurodegenerative Diseases
por: Ferrantelli, Flavia, et al.
Publicado: (2020)

Cell activation and HIV-1 replication in unstimulated CD4(+) T lymphocytes ingesting exosomes from cells expressing defective HIV-1
por: Arenaccio, Claudia, et al.
Publicado: (2014)

HIV-1 Nef Impairs Key Functional Activities in Human Macrophages through CD36 Downregulation
por: Olivetta, Eleonora, et al.
Publicado: (2014)

Anti-Cancer Vaccine for HPV-Associated Neoplasms: Focus on a Therapeutic HPV Vaccine Based on a Novel Tumor Antigen Delivery Method Using Endogenously Engineered Exosomes
por: Di Bonito, Paola, et al.
Publicado: (2019)

Simultaneous CD8(+) T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs
por: Ferrantelli, Flavia, et al.
Publicado: (2021)

Activation of Anti-SARS-CoV-2 Human CTLs by Extracellular Vesicles Engineered with the N Viral Protein
por: Manfredi, Francesco, et al.
Publicado: (2022)

Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses
por: Yong, Xin, et al.
Publicado: (2012)

Strong SARS-CoV-2 N-Specific CD8(+) T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice
por: Ferrantelli, Flavia, et al.
Publicado: (2022)

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
por: Zuo, Bingfeng, et al.
Publicado: (2020)

Antiviral effect of SARS-CoV-2 N-specific CD8(+) T cells induced in lungs by engineered extracellular vesicles
por: Manfredi, Francesco, et al.
Publicado: (2023)

SARS-CoV-2-Specific CD8(+) T-Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection
por: Ferrantelli, Flavia, et al.
Publicado: (2023)

CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides
por: Wu, Shu-Wei, et al.
Publicado: (2019)

Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb
por: Bolaños-Mateo, Elixabet, et al.
Publicado: (2014)

Prostaglandin E(2) and PD-1 mediated inhibition of antitumor CTL responses in the human tumor microenvironment
por: Miao, Jie, et al.
Publicado: (2017)

Cyclin G2 in macrophages triggers CTL-mediated antitumor immunity and antiangiogenesis via interferon-gamma
por: Liu, Lu, et al.
Publicado: (2022)

Broad CTL Response in Early HIV Infection Drives Multiple Concurrent CTL Escapes
por: Leviyang, Sivan, et al.
Publicado: (2015)

Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway
por: Lirussi, Darío, et al.
Publicado: (2017)

Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment through Mannose Receptor/CD206 Targeting
por: Fiani, Maria Luisa, et al.
Publicado: (2020)

Viral Vaccines and CTL Response
por: Woolard, Stacie N., et al.
Publicado: (2010)

Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation
por: Sun, Yunyan, et al.
Publicado: (2017)

NIH3T3 Directs Memory-Fated CTL Programming and Represses High Expression of PD-1 on Antitumor CTLs
por: Qin, Yingyu, et al.
Publicado: (2019)

Epitope Mapping and Computational Analysis of Anti-HPV16 E6 and E7 Antibodies in Single-Chain Format for Clinical Development as Antitumor Drugs
por: Amici, Carla, et al.
Publicado: (2020)

Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors
por: Andersen, Rikke Sick, et al.
Publicado: (2010)

Whole-Genome Immunoinformatic Analysis of F. tularensis: Predicted CTL Epitopes Clustered in Hotspots Are Prone to Elicit a T-Cell Response
por: Zvi, Anat, et al.
Publicado: (2011)

Introduction of a point mutation into an HLA class I single-chain trimer induces enhancement of CTL priming and antitumor immunity
por: Matsui, Masanori, et al.
Publicado: (2014)

Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses?
por: Ruggieri, Anna, et al.
Publicado: (2018)

Virus escape from CTL recognition
Publicado: (1994)

HIV CTL escape: at what cost?
por: Smith, Stephen M
Publicado: (2004)

Nicotine Inhibits Memory CTL Programming
por: Sun, Zhifeng, et al.
Publicado: (2013)

Functional Analysis of a CTL-X-Type Lectin CTL16 in Development and Innate Immunity of Tribolium castaneum
por: Bi, Jingxiu, et al.
Publicado: (2023)

Rejection of large HPV-16 expressing tumors in aged mice by a single immunization of VacciMax(® )encapsulated CTL/T helper peptides
por: Daftarian, Pirouz M, et al.
Publicado: (2007)

α(E)β(7) integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis
por: Floc'h, Audrey Le, et al.
Publicado: (2007)

Recombinant Modified Vaccinia Virus Ankara (MVA) Expressing Wild-Type Human p53 Induces Specific Antitumor CTL Expansion
por: Song, Guang-Yun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jfns91361rnrao45au6hceetof