Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”

The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell proliferation, survival, motility, and differentiation. The dysregulated activation of the receptor is often implicated in human cancers. EGFR is synthesized as a single-pass transmembrane protein, whi...

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Detalles Bibliográficos
Autores principales: Purba, Endang R., Saita, Ei-ichiro, Maruyama, Ichiro N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492017/
https://www.ncbi.nlm.nih.gov/pubmed/28574446
http://dx.doi.org/10.3390/cells6020013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492017/
https://www.ncbi.nlm.nih.gov/pubmed/28574446
http://dx.doi.org/10.3390/cells6020013

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