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Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”
The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell proliferation, survival, motility, and differentiation. The dysregulated activation of the receptor is often implicated in human cancers. EGFR is synthesized as a single-pass transmembrane protein, whi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492017/ https://www.ncbi.nlm.nih.gov/pubmed/28574446 http://dx.doi.org/10.3390/cells6020013 |