Synergistic Effect of Expressed miR-128 and Puma Protein on Targeted Induction of Tumor Cell Apoptosis

BACKGROUND: Puma is a highly robust pro-apoptotic protein. The protein becomes activated by p53 ensuing beyond-repair DNA damage. Downregulation of SIRT 1, by miR-128, elevates activated p53 that foment Puma indirectly. OBJECTIVES: In the present study, we used two-expression Adeno-Associated Virus...

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Detalles Bibliográficos
Autores principales: Khoshtinat Nikkhoi, Shahryar, Dorostkar, Ruhollah, Ranjbar, Saeed, Heydarzadeh, Hedieh, Tat, Mahdi, Ghalavand, Majdedin, Farasat, Alireza, Hashemzadeh, Mohammad Sadegh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Genetic Engineering and Biotechnology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492246/
https://www.ncbi.nlm.nih.gov/pubmed/28959335
http://dx.doi.org/10.15171/ijb.1429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492246/
https://www.ncbi.nlm.nih.gov/pubmed/28959335
http://dx.doi.org/10.15171/ijb.1429

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