Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling

[Image: see text] Defining specific pathways for efficient heat transfer from protein–solvent interfaces to their active sites represents one of the compelling and timely challenges in our quest for a physical description of the origins of enzyme catalysis. Enzymatic hydrogen tunneling reactions con...

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Detalles Bibliográficos
Autores principales: Offenbacher, Adam R., Hu, Shenshen, Poss, Erin M., Carr, Cody A. M., Scouras, Alexander D., Prigozhin, Daniil M., Iavarone, Anthony T., Palla, Ali, Alber, Tom, Fraser, James S., Klinman, Judith P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492416/
https://www.ncbi.nlm.nih.gov/pubmed/28691068
http://dx.doi.org/10.1021/acscentsci.7b00142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492416/
https://www.ncbi.nlm.nih.gov/pubmed/28691068
http://dx.doi.org/10.1021/acscentsci.7b00142

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