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Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell

Maple syrup is a natural sweetener that is commonly consumed worldwide. While maple syrup mainly comprises sucrose, it also contains phytochemicals that present various biological effects. Maple syrup is made by boiling down sap, and its color and composition vary in accordance with the sap collecti...

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Autores principales: Yamamoto, Tetsushi, Sato, Kanta, Kubota, Yuika, Mitamura, Kuniko, Taga, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492655/
https://www.ncbi.nlm.nih.gov/pubmed/28685052
http://dx.doi.org/10.3892/br.2017.910
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author Yamamoto, Tetsushi
Sato, Kanta
Kubota, Yuika
Mitamura, Kuniko
Taga, Atsushi
author_facet Yamamoto, Tetsushi
Sato, Kanta
Kubota, Yuika
Mitamura, Kuniko
Taga, Atsushi
author_sort Yamamoto, Tetsushi
collection PubMed
description Maple syrup is a natural sweetener that is commonly consumed worldwide. While maple syrup mainly comprises sucrose, it also contains phytochemicals that present various biological effects. Maple syrup is made by boiling down sap, and its color and composition vary in accordance with the sap collection season. Typically, seasonal progression is associated with darker syrup color, and antioxidant activity is proportional to the increasingly dark color. The authors previously reported that maple syrup demonstrated inhibitory effects on colorectal cancer cell growth and invasion, which correlated with darker maple syrup color. In the present study, they examined the effects of two different grades of maple syrup on gastrointestinal cancer cell proliferation, to investigate whether the dark-color maple syrup was suitable as a phytomedicine for gastrointestinal cancer treatment. Administration of dark-color maple syrup significantly inhibited gastrointestinal cancer cell growth as compared to non-treated cancer cells. Moreover, administration of dark-color maple syrup clearly inhibited protein kinase B (AKT) phosphorylation and did not impact mitogen-associated protein kinase phosphorylation. These data suggested that dark-color maple syrup may inhibit cell proliferation through suppression of AKT activation and, thus, may be suitable as a phytomedicine for gastrointestinal cancer treatment.
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spelling pubmed-54926552017-07-06 Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell Yamamoto, Tetsushi Sato, Kanta Kubota, Yuika Mitamura, Kuniko Taga, Atsushi Biomed Rep Articles Maple syrup is a natural sweetener that is commonly consumed worldwide. While maple syrup mainly comprises sucrose, it also contains phytochemicals that present various biological effects. Maple syrup is made by boiling down sap, and its color and composition vary in accordance with the sap collection season. Typically, seasonal progression is associated with darker syrup color, and antioxidant activity is proportional to the increasingly dark color. The authors previously reported that maple syrup demonstrated inhibitory effects on colorectal cancer cell growth and invasion, which correlated with darker maple syrup color. In the present study, they examined the effects of two different grades of maple syrup on gastrointestinal cancer cell proliferation, to investigate whether the dark-color maple syrup was suitable as a phytomedicine for gastrointestinal cancer treatment. Administration of dark-color maple syrup significantly inhibited gastrointestinal cancer cell growth as compared to non-treated cancer cells. Moreover, administration of dark-color maple syrup clearly inhibited protein kinase B (AKT) phosphorylation and did not impact mitogen-associated protein kinase phosphorylation. These data suggested that dark-color maple syrup may inhibit cell proliferation through suppression of AKT activation and, thus, may be suitable as a phytomedicine for gastrointestinal cancer treatment. D.A. Spandidos 2017-07 2017-05-16 /pmc/articles/PMC5492655/ /pubmed/28685052 http://dx.doi.org/10.3892/br.2017.910 Text en Copyright: © Yamamoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yamamoto, Tetsushi
Sato, Kanta
Kubota, Yuika
Mitamura, Kuniko
Taga, Atsushi
Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell
title Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell
title_full Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell
title_fullStr Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell
title_full_unstemmed Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell
title_short Effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell
title_sort effect of dark-colored maple syrup on cell proliferation of human gastrointestinal cancer cell
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492655/
https://www.ncbi.nlm.nih.gov/pubmed/28685052
http://dx.doi.org/10.3892/br.2017.910
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