Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia

BACKGROUND: Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial activation using an in vitro thrombin toxicity model applied to primary human micr...

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Detalles Bibliográficos
Autores principales: Yin, Min, Chen, Zhiying, Ouyang, Yetong, Zhang, Huiyan, Wan, Zhigang, Wang, Han, Wu, Wei, Yin, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492717/
https://www.ncbi.nlm.nih.gov/pubmed/28662718
http://dx.doi.org/10.1186/s12974-017-0887-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492717/
https://www.ncbi.nlm.nih.gov/pubmed/28662718
http://dx.doi.org/10.1186/s12974-017-0887-5

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