Cargando…

Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia

BACKGROUND: Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial activation using an in vitro thrombin toxicity model applied to primary human micr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yin, Min, Chen, Zhiying, Ouyang, Yetong, Zhang, Huiyan, Wan, Zhigang, Wang, Han, Wu, Wei, Yin, Xiaoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492717/ https://www.ncbi.nlm.nih.gov/pubmed/28662718 http://dx.doi.org/10.1186/s12974-017-0887-5

Ejemplares similares

Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1
por: Udawatte, Darshika J., et al.
Publicado: (2022)

miR-181a, delivered by hypoxic PTC-secreted exosomes, inhibits DACT2 by downregulating MLL3, leading to YAP-VEGF-mediated angiogenesis
por: Wang, Yingxue, et al.
Publicado: (2021)

Downregulation of miR-181b inhibits human colon cancer cell proliferation by targeting CYLD and inhibiting the NF-κB signaling pathway
por: Yang, Xifeng, et al.
Publicado: (2020)

TNFR1 and TNFR2, Which Link NF-κB Activation, Drive Lung Cancer Progression, Cell Dedifferentiation, and Metastasis
por: Shi, Gongping, et al.
Publicado: (2023)

MiR‐21‐5p/dual‐specificity phosphatase 8 signalling mediates the anti‐inflammatory effect of haem oxygenase‐1 in aged intracerebral haemorrhage rats
por: Ouyang, Yetong, et al.
Publicado: (2019)

miR-181d/RBP2/NF-κB p65 Feedback Regulation Promotes Chronic Myeloid Leukemia Blast Crisis
por: Zhou, Minran, et al.
Publicado: (2021)

TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α
por: Bruggeman, Leslie A., et al.
Publicado: (2011)

Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling
por: Li, J, et al.
Publicado: (2016)

CDK4 regulation by TNFR1 and JNK is required for NF-κB–mediated epidermal growth control
por: Zhang, Jennifer Y., et al.
Publicado: (2005)

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway
por: Balzano, Tiziano, et al.
Publicado: (2020)

NPS-1034 Induce Cell Death with Suppression of TNFR1/NF-κB Signaling in Testicular Cancer
por: Chen, Jian-Ting, et al.
Publicado: (2022)

TNFR2 promotes pancreatic cancer proliferation, migration, and invasion via the NF-κB signaling pathway
por: Gao, Zetian, et al.
Publicado: (2023)

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway
por: Jie, Zuliang, et al.
Publicado: (2021)

MALAT1 promotes liver fibrosis by sponging miR-181a and activating TLR4-NF-κB signaling
por: Wang, Yinghui, et al.
Publicado: (2021)

ETV7 reduces inflammatory responses in breast cancer cells by repressing the TNFR1/NF-κB axis
por: Meškytė, Erna Marija, et al.
Publicado: (2023)

Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia
por: Xiu, Yan, et al.
Publicado: (2018)

miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78
por: Luo, Chengyan, et al.
Publicado: (2017)

Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1
por: Cai, Xiaoli, et al.
Publicado: (2017)

Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the β-catenin and NF-κB pathways
por: Wang, Huiyan, et al.
Publicado: (2020)

Anti-Inflammatory Extract from Soil Algae Chromochloris zofingiensis Targeting TNFR/NF-κB Signaling at Different Levels
por: Leitner, Peter D., et al.
Publicado: (2022)

miR-150: targeting MLL leukemia
por: Jiang, Xi, et al.
Publicado: (2012)

OSR1 downregulation indicates an unfavorable prognosis and activates the NF-κB pathway in ovarian cancer
por: Yu, Zhong, et al.
Publicado: (2023)

PHLDA1 Expression is Controlled by an Estrogen Receptor (ER)-NFκB-miR-181 Regulatory Loop and is Essential for Formation of ER+ Mammospheres
por: Kastrati, Irida, et al.
Publicado: (2014)

miR-181a-5p targets DDX3X to inhibit the progression of osteoarthritis via NF-ΚB signaling pathway
por: Zhao, Peng, et al.
Publicado: (2023)

Quantitative characterization and analysis of the dynamic NF-κB response in microglia
por: Sheppard, Patrick W, et al.
Publicado: (2011)

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models
por: Indrieri, Alessia, et al.
Publicado: (2019)

Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells
por: Savva, Christiana G., et al.
Publicado: (2016)

TNFα‐induced abnormal activation of TNFR/NF‐κB/FTH1 in endometrium is involved in the pathogenesis of early spontaneous abortion
por: Wen, Yuting, et al.
Publicado: (2022)

Modulating the dynamics of NFκB and PI3K enhances the ensemble-level TNFR1 signaling mediated apoptotic response
por: Sherekar, Shubhank, et al.
Publicado: (2023)

The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor
por: Zhang, Li, et al.
Publicado: (2012)

Transforming growth factor-β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA-93-5p
por: Wang, Han, et al.
Publicado: (2021)

Dabigatran Monitoring Was Influenced by Thrombin Time Reagent With Different Thrombin Concentrations
por: Xu, Xiaoping, et al.
Publicado: (2019)

The interplay of LncRNA ANRIL and miR‐181b on the inflammation‐relevant coronary artery disease through mediating NF‐κB signalling pathway
por: Guo, Feng, et al.
Publicado: (2018)

Thrombin-Induced Microglia Activation Modulated through Aryl Hydrocarbon Receptors
por: Sheu, Meei-Ling, et al.
Publicado: (2023)

HIV-1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NF-κB pathway
por: Feng, Tingting, et al.
Publicado: (2016)

Downregulation of TLR4 by miR-181a Provides Negative Feedback Regulation to Lipopolysaccharide-Induced Inflammation
por: Jiang, Kangfeng, et al.
Publicado: (2018)

miR‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases
por: Carrella, Sabrina, et al.
Publicado: (2022)

The API2-MALT1 Fusion Exploits TNFR Pathway-associated RIP1 Ubiquitination to Promote Oncogenic NF-κB Signaling
por: Rosebeck, Shaun, et al.
Publicado: (2013)

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation
por: Bagnati, Marta, et al.
Publicado: (2016)

Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation
por: Jo, Eunbi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9jk3ihgu1d4ib993i593kqes69