Prediction of new Hsp90 inhibitors based on 3,4-isoxazolediamide scaffold using QSAR study, molecular docking and molecular dynamic simulation

BACKGROUND: Heat shock protein90 (Hsp90) are overexpressed in tumor cells, so the inhibition of the Hsp90 ATPase activity would be a significantly effective strategy in cancer therapy. METHODS: In the current study, 3,4-isoxazolediamide derivatives were suggested as an Hsp90 inhibitor for anti-cance...

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Detalles Bibliográficos
Autores principales: Abbasi, Maryam, Sadeghi-Aliabadi, Hojjat, Amanlou, Massoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493083/
https://www.ncbi.nlm.nih.gov/pubmed/28666484
http://dx.doi.org/10.1186/s40199-017-0182-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493083/
https://www.ncbi.nlm.nih.gov/pubmed/28666484
http://dx.doi.org/10.1186/s40199-017-0182-0

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