Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

BACKGROUND & AIMS: Currently most liver fibrosis research is performed in vivo, since suitable alternative in vitro systems which are able to recapitulate the cellular events leading to liver fibrosis are lacking. Here we aimed at generating a system containing cells representing the three key p...

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Detalles Bibliográficos
Autores principales: Prestigiacomo, Vincenzo, Weston, Anna, Messner, Simon, Lampart, Franziska, Suter-Dick, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493342/
https://www.ncbi.nlm.nih.gov/pubmed/28665955
http://dx.doi.org/10.1371/journal.pone.0179995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493342/
https://www.ncbi.nlm.nih.gov/pubmed/28665955
http://dx.doi.org/10.1371/journal.pone.0179995

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