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Design of nucleic acid sequences for DNA computing based on a thermodynamic approach
We have developed an algorithm for designing multiple sequences of nucleic acids that have a uniform melting temperature between the sequence and its complement and that do not hybridize non-specifically with each other based on the minimum free energy (ΔG(min)). Sequences that satisfy these constra...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549402/ https://www.ncbi.nlm.nih.gov/pubmed/15701762 http://dx.doi.org/10.1093/nar/gki235 |