The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

Colistin is an antimicrobial peptide that has become the only remaining alternative for the treatment of multidrug-resistant Gram-negative bacterial infections, but little is known of how clinical levels of colistin resistance evolve. We use in vitro experimental evolution and whole-genome sequencin...

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Detalles Bibliográficos
Autores principales: Jochumsen, Nicholas, Marvig, Rasmus L., Damkiær, Søren, Jensen, Rune Lyngklip, Paulander, Wilhelm, Molin, Søren, Jelsbak, Lars, Folkesson, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494192/
https://www.ncbi.nlm.nih.gov/pubmed/27694971
http://dx.doi.org/10.1038/ncomms13002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494192/
https://www.ncbi.nlm.nih.gov/pubmed/27694971
http://dx.doi.org/10.1038/ncomms13002

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