Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

Chronic lymphocytic leukaemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, here we present genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients measured...

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Detalles Bibliográficos
Autores principales: Rendeiro, André F., Schmidl, Christian, Strefford, Jonathan C., Walewska, Renata, Davis, Zadie, Farlik, Matthias, Oscier, David, Bock, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494194/
https://www.ncbi.nlm.nih.gov/pubmed/27346425
http://dx.doi.org/10.1038/ncomms11938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494194/
https://www.ncbi.nlm.nih.gov/pubmed/27346425
http://dx.doi.org/10.1038/ncomms11938

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