siRNA target site secondary structure predictions using local stable substructures

The crystal structure based model of the catalytic center of Ago2 revealed that the siRNA and the mRNA must be able to form an A-helix for correct positing of the scissile phosphate bond for cleavage in RNAi. This suggests that base pairing of the target mRNA with itself, i.e. secondary structure, m...

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Detalles Bibliográficos
Autores principales: Heale, Bret S. E., Soifer, Harris S., Bowers, Chauncey, Rossi, John J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549425/
https://www.ncbi.nlm.nih.gov/pubmed/15722476
http://dx.doi.org/10.1093/nar/gni026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549425/
https://www.ncbi.nlm.nih.gov/pubmed/15722476
http://dx.doi.org/10.1093/nar/gni026

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