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Substituting Tyr(138) in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation
Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and a high activity, and that the substrate l‐Phe is the key player...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494296/ https://www.ncbi.nlm.nih.gov/pubmed/28680815 http://dx.doi.org/10.1002/2211-5463.12243 |