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Redox modulation of thimet oligopeptidase activity by hydrogen peroxide

Thimet oligopeptidase (EC 3.4.24.15, TOP) is a cytosolic mammalian zinc protease that can process a diversity of bioactive peptides. TOP has been pointed out as one of the main postproteasomal enzymes that process peptide antigens in the MHC class I presentation route. In the present study, we descr...

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Detalles Bibliográficos
Autores principales: Icimoto, Marcelo Y., Ferreira, Juliana C., Yokomizo, César H., Bim, Larissa V., Marem, Alyne, Gilio, Joyce M., Oliveira, Vitor, Nantes, Iseli L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494303/
https://www.ncbi.nlm.nih.gov/pubmed/28680816
http://dx.doi.org/10.1002/2211-5463.12245