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Template-directed ligation on repetitive DNA sequences: a chemical method to probe the length of Huntington DNA
Several genomic disorders are caused by an excessive number of DNA triplet repeats. We developed a DNA-templated reaction in which product formation occurs only when the number of repeats exceeds a threshold indicative for the outbreak of Chorea Huntington. The combined use of native chemical PNA li...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494559/ https://www.ncbi.nlm.nih.gov/pubmed/28706635 http://dx.doi.org/10.1039/c4sc01974a |