Linking E-cadherin mechanotransduction to cell metabolism through force mediated activation of AMPK

The response of cells to mechanical force is a major determinant of cell behavior and is an energetically costly event. How cells derive energy to resist mechanical force is unknown. Here, we show that application of force to E-cadherin stimulates Liver Kinase B1 (LKB1) to activate AMP-activated pro...

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Detalles Bibliográficos
Autores principales: Bays, Jennifer L., Campbell, Hannah K., Heidema, Christy, Sebbagh, Michael, DeMali, Kris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494977/
https://www.ncbi.nlm.nih.gov/pubmed/28553939
http://dx.doi.org/10.1038/ncb3537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494977/
https://www.ncbi.nlm.nih.gov/pubmed/28553939
http://dx.doi.org/10.1038/ncb3537

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