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Linking E-cadherin mechanotransduction to cell metabolism through force mediated activation of AMPK
The response of cells to mechanical force is a major determinant of cell behavior and is an energetically costly event. How cells derive energy to resist mechanical force is unknown. Here, we show that application of force to E-cadherin stimulates Liver Kinase B1 (LKB1) to activate AMP-activated pro...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494977/ https://www.ncbi.nlm.nih.gov/pubmed/28553939 http://dx.doi.org/10.1038/ncb3537 |