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Mechanisms of precise genome editing using oligonucleotide donors

The use of programmable meganucleases is transforming genome editing and functional genomics. CRISPR/Cas9 was developed such that targeted genomic lesions could be introduced in vivo with unprecedented ease. In the presence of homology donors, these lesions facilitate high-efficiency precise genome...

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Detalles Bibliográficos
Autores principales:	Kan, Yinan, Ruis, Brian, Takasugi, Taylor, Hendrickson, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495063/ https://www.ncbi.nlm.nih.gov/pubmed/28356322 http://dx.doi.org/10.1101/gr.214775.116

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