Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

Type II topoisomerases orchestrate proper DNA topology, and they are the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations. Here, we develop a high-throughput sequencing technology to define TOP2 cleavage sites at single-base precision, and use the tech...

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Detalles Bibliográficos
Autores principales: Yu, Xiang, Davenport, James W., Urtishak, Karen A., Carillo, Marie L., Gosai, Sager J., Kolaris, Christos P., Byl, Jo Ann W., Rappaport, Eric F., Osheroff, Neil, Gregory, Brian D., Felix, Carolyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495075/
https://www.ncbi.nlm.nih.gov/pubmed/28385713
http://dx.doi.org/10.1101/gr.211615.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495075/
https://www.ncbi.nlm.nih.gov/pubmed/28385713
http://dx.doi.org/10.1101/gr.211615.116

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