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Settling the m(6)A debate: methylation of mature mRNA is not dynamic but accelerates turnover

Post-transcriptional modification of RNA nucleosides has been implicated as a pivotal regulator of mRNA biology. In this issue of Genes & Development, Ke and colleagues (pp. 990–1006) provide insights into the temporal and spatial distribution of N(6)-methyladenosine (m(6)A) in RNA transcripts b...

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Detalles Bibliográficos
Autores principales: Rosa-Mercado, Nicolle A., Withers, Johanna B., Steitz, Joan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495124/
https://www.ncbi.nlm.nih.gov/pubmed/28637691
http://dx.doi.org/10.1101/gad.302695.117