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A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo
Cancer growth is a multi-stage, stochastic evolutionary process. While cancer genome sequencing has been instrumental in identifying the genomic alterations that occur in human tumors, the consequences of these alterations on tumor growth remains largely unexplored. Conventional genetically engineer...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495136/ https://www.ncbi.nlm.nih.gov/pubmed/28530655 http://dx.doi.org/10.1038/nmeth.4297 |