APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high frequency. APOL1 is a trypanolytic protein that co...

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Detalles Bibliográficos
Autores principales: Cooper, Anneli, Ilboudo, Hamidou, Alibu, V Pius, Ravel, Sophie, Enyaru, John, Weir, William, Noyes, Harry, Capewell, Paul, Camara, Mamadou, Milet, Jacqueline, Jamonneau, Vincent, Camara, Oumou, Matovu, Enock, Bucheton, Bruno, MacLeod, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495568/
https://www.ncbi.nlm.nih.gov/pubmed/28537557
http://dx.doi.org/10.7554/eLife.25461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495568/
https://www.ncbi.nlm.nih.gov/pubmed/28537557
http://dx.doi.org/10.7554/eLife.25461

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