HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and results in vascular inflammation and ultimately atherosclerosis. However, how DF alters EC metabolism, and whether resulting metabolic changes in...

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Detalles Bibliográficos
Autores principales: Wu, David, Huang, Ru-Ting, Hamanaka, Robert B, Krause, Matt, Oh, Myung-Jin, Kuo, Cheng-Hsiang, Nigdelioglu, Recep, Meliton, Angelo Y, Witt, Leah, Dai, Guohao, Civelek, Mete, Prabhakar, Nanduri R, Fang, Yun, Mutlu, Gökhan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495571/
https://www.ncbi.nlm.nih.gov/pubmed/28556776
http://dx.doi.org/10.7554/eLife.25217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495571/
https://www.ncbi.nlm.nih.gov/pubmed/28556776
http://dx.doi.org/10.7554/eLife.25217

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