Cargando…

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium

Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and results in vascular inflammation and ultimately atherosclerosis. However, how DF alters EC metabolism, and whether resulting metabolic changes in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, David, Huang, Ru-Ting, Hamanaka, Robert B, Krause, Matt, Oh, Myung-Jin, Kuo, Cheng-Hsiang, Nigdelioglu, Recep, Meliton, Angelo Y, Witt, Leah, Dai, Guohao, Civelek, Mete, Prabhakar, Nanduri R, Fang, Yun, Mutlu, Gökhan M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495571/ https://www.ncbi.nlm.nih.gov/pubmed/28556776 http://dx.doi.org/10.7554/eLife.25217

Ejemplares similares

HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury
por: Woods, Parker S, et al.
Publicado: (2022)

Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release
por: Cetin-Atalay, Rengul, et al.
Publicado: (2021)

Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells
por: Cetin-Atalay, Rengul, et al.
Publicado: (2022)

Impaired Clearance of Influenza A Virus in Obese, Leptin Receptor Deficient Mice Is Independent of Leptin Signaling in the Lung Epithelium and Macrophages
por: Radigan, Kathryn A., et al.
Publicado: (2014)

Similarities in the Metabolic Reprogramming of Immune System and Endothelium
por: Tang, Chu-Yik, et al.
Publicado: (2017)

Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice
por: Cetin-Atalay, Rengul, et al.
Publicado: (2023)

HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase
por: Nanduri, Jayasri, et al.
Publicado: (2015)

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response
por: Sun, Kaitlyn A, et al.
Publicado: (2020)

Particulate Matter Air Pollution: Effects on the Cardiovascular System
por: Hamanaka, Robert B., et al.
Publicado: (2018)

The Airway Epithelial Response to Air Pollution: It’s Not Just Inflammation
por: Hamanaka, Robert B., et al.
Publicado: (2020)

Our Compliments to the Authors: Decay Accelerating Factor and the Complement System in Pulmonary Fibrosis
por: Hamanaka, Robert B., et al.
Publicado: (2022)

Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium
por: Oyama, Yoshimasa, et al.
Publicado: (2019)

Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice
por: Mutlu, Ece A, et al.
Publicado: (2011)

HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis
por: Toullec, Aurore, et al.
Publicado: (2017)

Direct cell reprogramming for tissue engineering and regenerative medicine
por: Grath, Alexander, et al.
Publicado: (2019)

Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo
por: Chung, Jihwa, et al.
Publicado: (2016)

Endothelium-Released Microvesicles Transport miR-126 That Induces Proangiogenic Reprogramming in Monocytes
por: Arderiu, Gemma, et al.
Publicado: (2022)

Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus
por: Sobrevia, Luis, et al.
Publicado: (2016)

Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis
por: Tiwari, Ratnakar, et al.
Publicado: (2023)

Particulate Matter-Induced Lung Inflammation Increases Systemic Levels of PAI-1 and Activates Coagulation Through Distinct Mechanisms
por: Budinger, G. R. Scott, et al.
Publicado: (2011)

EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis
por: Onufer, Emily J., et al.
Publicado: (2020)

The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells
por: Battello, Nadia, et al.
Publicado: (2016)

Transcription Factor KLF14 and Metabolic Syndrome
por: Yang, Qianyi, et al.
Publicado: (2020)

Recent advances in understanding the physiology of hypoxic sensing by the carotid body
por: Prabhakar, Nanduri R., et al.
Publicado: (2018)

Impacted gutkha presenting as an intrabronchial mass lesion leading to post-obstructive pneumonia
por: Bhardwaj, Swati, et al.
Publicado: (2022)

Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming
por: Tiwari, Ratnakar, et al.
Publicado: (2022)

Investigation of the Relationship between Vestibular Disorders and Sleep Disturbance
por: Mutlu, Basak, et al.
Publicado: (2022)

Genetic regulation of circular RNA expression in human aortic smooth muscle cells and vascular traits
por: Aherrahrou, Redouane, et al.
Publicado: (2022)

Reprogramming the Transcriptional Response to Hypoxia with a Chromosomally Encoded Cyclic Peptide HIF-1 Inhibitor
por: Mistry, Ishna N., et al.
Publicado: (2016)

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance
por: Nagao, Ayako, et al.
Publicado: (2019)

Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming
por: Jin, Jinmei, et al.
Publicado: (2019)

STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection
por: Gomes, Marco Tulio R., et al.
Publicado: (2021)

Gasotransmitter Regulation of Ion Channels: A Key Step in O(2) Sensing By the Carotid Body
por: Prabhakar, Nanduri R., et al.
Publicado: (2014)

Hydroxysafflor Yellow A Blocks HIF-1α Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium
por: Li, Yi, et al.
Publicado: (2022)

The Endothelium in Acromegaly
por: Maffei, Pietro, et al.
Publicado: (2019)

Endothelium, for Example
por: Henderson, Andrew
Publicado: (1996)

The aging endothelium
por: Ting, Ka Ka, et al.
Publicado: (2021)

Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study
por: Andueza, Aitor, et al.
Publicado: (2020)

Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming
por: Fessel, Joshua P., et al.
Publicado: (2012)

Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure
por: Wang, Ning, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_15risaqcrcprtbkg8flm0jg196