Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

The ends of linear chromosomes are capped by protein–DNA complexes termed telomeres. Telomere repeat binding factors 1 and 2 (TRF1 and TRF2) bind specifically to duplex telomeric DNA and are critical components of functional telomeres. Consequences of telomere dysfunction include genomic instability...

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Detalles Bibliográficos
Autores principales: Opresko, Patricia L., Fan, Jinshui, Danzy, Shamika, Wilson, David M., Bohr, Vilhelm A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549571/
https://www.ncbi.nlm.nih.gov/pubmed/15731343
http://dx.doi.org/10.1093/nar/gki273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549571/
https://www.ncbi.nlm.nih.gov/pubmed/15731343
http://dx.doi.org/10.1093/nar/gki273

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