Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

In this study we have tested the efficacy of citrate therapy in various cancer models. We found that citrate administration inhibited A549 lung cancer growth and additional benefit accrued in combination with cisplatin. Interestingly, citrate regressed Ras-driven lung tumors. Further studies indicat...

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Detalles Bibliográficos
Autores principales: Ren, Jian-Guo, Seth, Pankaj, Ye, Huihui, Guo, Kun, Hanai, Jun-ichi, Husain, Zaheed, Sukhatme, Vikas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495754/
https://www.ncbi.nlm.nih.gov/pubmed/28674429
http://dx.doi.org/10.1038/s41598-017-04626-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495754/
https://www.ncbi.nlm.nih.gov/pubmed/28674429
http://dx.doi.org/10.1038/s41598-017-04626-4

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